Manohar Parrikar was born in Masupa, Goa. He studied at Loyola High School. He completed his secondary education in Marathi and went on to graduate in metallurgical engineering from the Indian Institute of Technology, Bombay in 1998. He was the first IIT alumnus to serve as MLA of an Indian state.

Parrikar joined the Rashtriye Swayamsevak Sangh (RSS) at a young age and became a mukhya shikshak (chief instructor) in the final years of his schooling.

Parrikar belongs to the Goud Saraswat Brahmin (GSB) community which is a fish-eating Brahmins caste that reside in the western coast of India. His wife Medha died in 2001. They have two sons.

Manohar Parrikar was an Indian Politician and leader of Bhartiya Janta Party who was the Chief Minister of Goa from 14 March 2017 till his death. Previously, he was the chief minister of Goa from 2000 to 2005 and from 2012 to 2014.  He served in the National Democratic Alliance government under Prime Minister Narendra Modi as Defense Minister of India from 2014 to 2017. He was a former member of the Rajya Sabha from Uttar Pradesh

As of March–June 2018, Parrikar was undergoing treatment for a pancreatic ailment at a hospital in the US. He returned to India and in September was admitted in the AIIMS, Delhi for treatment. On 27 October 2018 the Goa government announced that CM Manohar Parrikar has pancreatic cancer.

He died on 17 March 2019 at the age of 63 from pancreatic cancer at his residence in Panaji. His death was announced by the president of India, Ram Nath Kovind.